On the other hand, regarding the neuroinflammation of AD, it has been widely documented in the literature that AD patients overexpress the enzyme cyclooxygenase 2 (COX-2) in the cortex and the hippocampus [36,37,38,189], thus increasing the formation of pro-inflammatory prostaglandins PGD2 and PGE2 [190]. The gene discussed is PTGS2; the disease is Alzheimer disease.