Meanwhile, Tf facilitating T7 uptake in vivo has been confirmed which attracts T7 peptide being applied in a cancer-targeting drug delivery system [26,27,28] In this study, we took advantage of NPs and targeting ability of T7 peptide to facilitate seliciclib uptake by cancer cells and achieve a better cytotoxicity effect in TfR-overexpressed cancer cells. This evidence concerns the gene TF and cancer.