RUNX1 and acute myeloid leukemia: The most frequent chromosomal translocations/PFGs observed in the AML patients are t(8;21) RUNX1-RUNX1T1, t(15;17) PML-RARα, and rearrangements of the KMT2A gene as t(9;11) KMT2A-MLLT3 [3].