VWF and hepatocellular carcinoma: Moreover, other platelet-stored factors, including vWF, 5-HT and sphingosine-1-phosphate (S1P), exert a pro-fibrotic effect: the depletion of vWF in mice with CCl4-induced fibrosis reduces the fibrotic area and improves liver function [92], and vWF could represent a useful biomarker for liver fibrosis and HCC in patients with HBV and HCV [93].