Further analysis revealed enrichment for CD8+ and activated T cells in the tumours of mice receiving LTS-FMT, while the tumours from STS-FMT mice were enriched in immunosuppressive regulatory T cells, suggesting that the microbiome might indeed have a profound local as well as systemic effect in shaping the tumour microenvironment and consequently modulating tumour progression. The gene discussed is CD8A; the disease is neoplasm.