The high-risk (MBN Sig-high) subgroup, characterized by higher expression levels of MYC and BCL-2 and a lower expression of NFKBIA, could be used to identify a significant fraction of ABC DLBCLs and the vast majority of double-hit cases, allowing for further risk stratification within the GCB/U subset. This evidence concerns the gene MYC and aneurysmal bone cyst.