In fact, it is not uncommon to encounter cases that could be regarded as DLBCL-NOS but are ultimately classified as HGBCL due to the detection of double or triple hits (D/TH) of MYC, BCL2, and/or BCL6 (HGBCL-D/TH) by FISH, as underlined by Sehn and Salles in their review on DLBCL published in the New England Journal of Medicine on 4 March 2021 [7] (see below). Here, BCL6 is linked to diffuse large B-cell lymphoma.