Interestingly, MLL2 mutations were associated with those of MYC, while TP53 mutations occurred in a mutually exclusive fashion with KLHL6. CRISPR screening revealed that knockout of EBF1, IRF4, CARD11, MYD88, and IKBKB was selectively lethal in ABC DLBCL cell lines, as was knockout of ZBTB7A, XPO1, TGFBR2, and PTPN6 in the GCB lines. This evidence concerns the gene IRF4 and aneurysmal bone cyst.