For this reason, the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved these two anti-PD-1 drugs (nivolumab and pembrolizumab), for the treatment of refractory/relapsed (R/R) HL [1,2] with the intent to reactivate the immune system and restore immunity against Hodgkin Reed-Sternberg cells [3]. Here, PDCD1 is linked to Hodgkins lymphoma.