Dunnigan disease, or FPLD2, is considered to be one of a group of rare disorders known as laminopathies, which result from pathogenic variants in the LMNA gene (primary laminopathies), or other genes that influence lamin processing or the proper functioning of lamin A on chromatin, such as ZMPSTE24 gene variants in type B mandibuloacral dysplasia [25], or BANF1 gene variants in Nestor–Guillermo progeria syndrome [26], respectively (secondary laminopathies). This evidence concerns the gene ZMPSTE24 and laminopathy.