However, for the severe CD4 nadir category, the risk of cancer persisted at 5 years (RR = 2.33, 95% CI [1.27, 4.11], p = 0.0042) and at 10 years (RR = 1.77, 95% CI [1.04, 3.02], p = 0.0305). The gene discussed is CD4; the disease is cancer.