Schmidt et al. used the resources of the Breast Cancer Association Consortium (BCAC) including 44,777 women with breast cancer and 42,997 unaffected women from 33 studies and estimated the odds ratio (OR) for invasive breast cancer as 2.30 (95% Confidence Interval, 1.90–2.69) which was predominantly a risk for estrogen receptor (ER) positive disease OR 2.55 (95% CI, 2.10–3.10) [14]. Here, ESR1 is linked to invasive breast carcinoma.