A meta-analysis of breast cancer risk associated with CHEK2 c.1100delC estimated an odds ratio (OR) of 2.7 (95% CI, 2.1–3.4) for unselected breast cancer cases and OR 4.8 (95% CI, 3.3–7.2) for women with a family history of breast cancer [6]. This evidence concerns the gene CHEK2 and breast carcinoma.