The data indicated that the aberrant circulating hypermethylated CCDC181, GCM2 and ITPRIPL1 detected in the plasma samples were also significantly present in the associated tumor tissues of breast cancer patients (Spearman’s rho = 0.702, 0.497 and 0.634, all p < 0.001, Figure 5). This evidence concerns the gene ITPRIPL1 and breast cancer.