In one small study utilizing the Sepsis-3 criteria in patients with sepsis and septic shock, those with septic shock demonstrated significantly elevated plasma levels of PTX3, MCP1, and Ang-2 and low levels of Ang-1 [30], and Ang2 levels in sepsis patients were significantly higher than in those patients without sepsis (p < 0.05), with AUC 0.631 (95% CI 0.464–0.799, p = 0.1288) for Ang2 expression in septic shock patients. The gene discussed is ANGPT2; the disease is Sepsis.