Another prospective single-centered study showed that serum PTX3 levels could identify both the diagnosis and severity of sepsis with AUC of 0.84 for PTX3 (95% CI, 0.95–0.99; p < 0.001) with optimal cut-off values of 15.10 ng/mL (sensitivity, 92.6%; specificity, 97.4%; p < 0.001)., suggesting that PTX3 has a diagnostic value comparable to that of IL-6 in sepsis and septic shock [30]. This evidence concerns the gene IL6 and Sepsis.