In several clinical studies of sepsis, both a high level of Ang-2 and a low level of Ang-1 or high Ang-2/Ang-1 and low Ang-1/Ang-2 ratios have been associated with poor clinical outcomes, organ dysfunction, and adverse outcomes in sepsis, including predicting the severity of acute respiratory distress syndrome (ARDS) [60,61]. This evidence concerns the gene ANGPT1 and acute respiratory distress syndrome.