In one study of patients with sepsis and septic shock diagnosed according to Sepsis-3, serum IL-6 could discriminate sepsis (area under the curve (AUC), 0.83–0.94, p  < 0.001, 80.4% sensitivity, 88.9% specificity) from controls; however, for distinguishing septic shock (AUC, 0.71–0.89, 76.1% sensitivity, 78.4% specificity) from sepsis, optimal cutoff value was similar to pentraxin 3 (PT3) and PCT [25]. This evidence concerns the gene IL6 and septic shock.