CD8A and colorectal carcinoma: In syngeneic mouse models of CRC, high dose irradiation (1 × 10 Gy and 1 × 30 Gy) promoted the expansion of effector CD8+ T cells and a loss of MDSCs via activation of antigen cross-presenting DCs, secretion of IFN-γ, and activation of CD4+ T cells expressing CD40L [152,153].