TIGIT and neoplasm: In a syngeneic mouse model of CC, Grapin and colleagues showed that, compared to 18 × 2 Gy and 1 × 16.4 Gy, 3 × 8 Gy irradiation induced the greatest increase in TILs and expression of PD-L1 and TIGIT and this protocol was even more effective in controlling tumor development when associated with anti-PD-L1 and anti-TIGIT treatment [162].