For instance, several groups have observed desirable effects from restoring miR-34 in reducing tumor burden in murine models of NSCLC [259,260,261], with similar efforts having been made to examine the effects of restoring other tumor suppressors such as miR-29 [262], let-7 [177], and MEG3 [190]. This evidence concerns the gene MEG3 and non-small cell lung carcinoma.