Further, increased expression of miR-146 in lung cancer cells lowers the level of claudin-12, which in turn leads to activation of the Wnt/β-catenin and PI3K/AKT/MAPK signaling pathways resulting in the increased viability and migration, as well as resistance to cisplatin and inhibition of apoptosis [164]. This evidence concerns the gene PIK3CA and lung carcinoma.