ADCY10 and major depressive disorder: Therefore, it can be inferred that SAC might have a steroidogenic effect on other organs such as the adrenal gland and brain by activating this pathway, although SAC has already been reported to have a neuroprotective effect on isolated hippocampal neuron cell culture, in addition to amelioration of memory function and depression in animal models by other mechanisms [37,38,39,40].