Treatment of alloxan-induced diabetic rats for 14 days with aqueous extract of V. paradoxa bark (125, 250 and 500 mg/kg bw, orally) increased the level of GSH and the activities of SOD and CAT enzymes in the liver of diabetic rats, suggesting that V. paradoxa extract may reduce diabetes-associated complications [38]. Here, SOD1 is linked to diabetes mellitus.