Also, prolonged (3 months or 6 months) treatment of STZ-induced diabetic mice with sulforaphane significantly activated Nrf-2 signaling and mRNA expression of NQO1, HO-1, metallothionein (MT), SOD1, SOD2 and CAT in the heart of diabetic mice and prevented diabetes-induced cardiac oxidative damage, hypertrophy, inflammation, and fibrosis [87]. This evidence concerns the gene SOD2 and diabetes mellitus.