In another study, supplementation of T2D db/db mice with quercetin for six weeks, reduced plasma total cholesterol (TC) and increased HDL, lowered the level of TBARS and improved activities of CAT, SOD and GPx in the liver, indicating hypolipidemic and antioxidant effects of quercetin in T2D [61]. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.