In another study, oral resveratrol administration to T2D rats (5 mg/kg/day for 4 months) induced cardiac SOD and CAT activities, reduced oxidative markers (oxidized/reduced GSH ratio, nitrite/nitrate, 8-isoprostane, NF-kB activity) and improved left ventricular pressure and coronary flow [79]. Here, SOD1 is linked to type 2 diabetes mellitus.