LAPTM5 and Alzheimer disease: (i) genes that are upregulated in AD brains [49], for example, Fam107 and Itpkb (Table 2); (ii) genes annotated to innate immunity and microglia, for example, Entpd1 [50] or mpeg1, which was shown to be increased in APPPS1 mice [51] (Table 3); and (iii) genes annotated to adaptive immunity and T-cells, for example, Laptm5, which is associated with abnormal T-cell activation and increased T-cell proliferation and identified as a new genetic risk locus for AD [52] (Table 4).