ALOX5 and Alzheimer disease: In the context of AD, expression of 5-lipoxygenase (5-Lox), the rate-limiting enzyme in the LT pathway, is elevated in the hippocampus of the Tg2576 amyloid model and in the hippocampus of AD patients [23,24] and was found in microglia and neurons of APP-PS1 mice and AD patients [25].