DES and familial dilated cardiomyopathy: Other well-known causal genes of DCM are those encoding lamin A/C (LMNA), troponin T2 (TNNT2), phospholamban (PLB), desmin (DES), tropomyosin (TPM), vinculin (VCL), and RNA-binding motif protein 20 (RBM20) proteins.