Multiple gene variants can also exert additive effects, as shown by Deacon D.C. et al., who generated patient-derived and isogenic hiPSC-CMs that were genome-edited via CRISPR/Cas9 to create an allelic series of TPM1 and VCL variants and proved that compound genetic variants can combinatorially interact to induce DCM, particularly when influenced by other disease-provoking stressors [74]. Here, VCL is linked to familial dilated cardiomyopathy.