TSPAN8 and neoplasm: By comparing a wild-type ASML cell line with CD151-knockdown and/or Tspan8-knockdown clones, Yue et al. showed that tumor-derived exosomal proteins Tspan8 and CD151 are involved both in promoting ECM degradation, through the activation of associated proteases and integrins, as well as in reprogramming hematopoietic cells towards an inflammatory phenotype, by inducing the overexpression of chemokine/chemokine receptors in stroma cells [47] Moreover, CD151/Tspan8-competent tumor exosomes promote EMT in non-metastatic cells [47].