In particular, hypoxic PC cell-derived exosomal miR-301a-3p promotes the polarization of M1 macrophages towards an M2 phenotype by activating the phosphatase and tensin homolog/phosphoinositide 3-kinase gamma (PTEN/PI3Kγ) pathway, which in turn stimulates migration, invasion, and EMT of PC cells [40]. Here, PTEN is linked to pachyonychia congenita.