Additionally, overexpression of a H3K4 histone demethylase, Jumonji, AT Rich Interactive Domain 1A (JARID1A) leads to the activation of cyclin D1/E1 and Integrin Subunit Beta 1 (ITGB1) expression, promoting lung cancer cell growth and metastasis [81]. Here, ITGB1 is linked to lung carcinoma.