The Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX/KDM6A) demethylase activates several oncogenes and pro-metastatic genes, such as metalloproteinases MMP-9/11 and Homeobox protein Sineoculis homeobox homolog 1, Sine Oculis Homeobox Homolog 1 (SIX1), upon interaction with the H3K4 methyltransferase, MLL4 complex, enhancing EMT and breast cancer metastasis [100]. This evidence concerns the gene SIX1 and breast carcinoma.