PRICKLE1 and cancer: EZH2 mediates the H3K27me3 marker which has been associated to silencing of the CDH1 gene, Wnt antagonist genes such as Axis Inhibition Protein 2 (AXIN2), Naked1 (NKD1), Protein Phosphatase 2 Regulatory Subunit 2 beta (PPP2R2B), Prickle Planar Cell Polarity Protein 1 (PRICKLE1), Secreted Frizzled Related Protein 5 (SFRP5) and of the metastasis suppressor gene Raf Kinase Inhibitory Protein (RKIP) [22], promoting EMT and cancer metastasis [23] (Figure 3).