JAM2 and cancer: LncRNA homeobox (HOX) Transcript Antisense RNA (HOTAIR) that has been associated to metastasis and poor prognosis in several cancer types [61], can interact with both PRC2 and LSD1 in order to repress HOX genes such as HOXD8, HOXD9, HOXD10, HOXD11 along with other metastasis suppressor genes, such as P53-Responsive Gene 1 (PRG1), Junctional Adhesion Molecule 2 (JAM2), Protocadherin 10 (PCDH10), and Protocadherin Beta 5 (PCDHB5) [62].