CDH1 and cancer: Histone 3 lysine 4 acetylation (H3K4Ac) marks mediated by TIP60, are often detected in the promoters of EMT marker genes, including CDH1, glioma-associated oncogene homolog 1 (GLI1) and smoothened homolog precursor (SMO) of the Hedgehog pathway which are involved in cancer cell migration and invasion [13].