Another BRD4 inhibitor JQ1 along with MS417 were demonstrated to interfere with BRD4 binding to Keratin 73 (K73)/K76Ac2 on TWIST transcription factor and repress WNT5A expression, thus reversing EMT and metastasis of breast cancer in vitro and in vivo [122]. The gene discussed is BRD4; the disease is breast cancer.