The involvement of Bcl-xL in melanoma progression was also proved by Liqing Zhuang’s group via immunohistology analysis of Bcl-xL and other anti-apoptotic proteins, as Bcl-2 and Mcl-1, in sections of benign nevi, primary melanoma and metastatic melanoma [68]. Here, BCL2L1 is linked to metastatic melanoma.