As the BH4 domain is capable of binding to other proteins that do not belong to the Bcl-2 family, some anti-apoptotic members, including Bcl-xL, are capable of more than just inhibition of apoptosis to which are traditionally associated, specifically contributing to other important cellular functions, such as proliferation, autophagy, differentiation, DNA repair, tumor progression and angiogenesis [42]. Here, BCL2 is linked to neoplasm.