On the contrary, the study of Olie and collaborators performed using antisense oligonucleotides directed against either Bcl-xL mRNA or the Bcl-2 and the Bcl-xL mRNAs simultaneously [99] demonstrated that both the Bcl-xL monospecific oligonucleotide and the Bcl-2/Bcl-xL bispecific oligonucleotide reduced tumor cell viability by induction of apoptosis, but the bispecific oligonucleotide proved to be superior to the monospecific ones. This evidence concerns the gene BCL2L1 and neoplasm.