Clinical evaluation of CD4-IRF4KO mice immunized with IRBP/CFA by Fundoscopy, histology and optical coherence tomography revealed development of hallmark features of uveitis characterized by massive infiltration of inflammatory cells into the retina and destruction of photoreceptor cells are significantly suppressed in the CD4-IRF4KO compared to WT mice. The gene discussed is CD4; the disease is uveitis.