Dobri and colleagues recently reported that with modern highly sensitive GH assays, a nadir GH ≥ 0.4 μg/L following OGTT may be used for the diagnosis of acromegaly in patients with impaired fasting glucose, impaired glucose tolerance, or relatively well-controlled diabetes mellitus with glycated hemoglobin <8% [22]. This evidence concerns the gene GH1 and acromegaly.