The 2014 Endocrine Society Clinical Practice Guideline on acromegaly recommend measurement of IGF-1 levels in patients with typical clinical manifestations of acromegaly, especially the classical acral and facial features, or in patients who have several of the associated conditions, including sleep apnea, hypertension, type 2 diabetes mellitus, arthritis, carpal tunnel syndrome, and hyperhidrosis. The gene discussed is IGF1; the disease is diabetes mellitus.