CRH and Nasal polyposis: If the hypothesis that human airway mucosa MCs are activated under conditions of perceived stress via CRH/CRH-R stimulation is confirmed in situ, CRH and CRH-Rs would become promising novel targets for therapeutic interventions in a wide range of stress-aggravated, MC-dependent human airway diseases ranging from bronchial asthma via allergic rhinoconjunctivitis to nasal polyposis [44,45,46,47].