This raises the question as to whether these effects also extend to mucosa MC populations in other organs and whether CRH-R antagonists and/or anti-SCF can be exploited in other MC-dependent inflammatory and allergic diseases aggravated by psychological stress [79], ranging from allergic rhinoconjunctivitis, allergic asthma and food allergy to inflammatory bowel disease, anaphylaxis, and urticaria [47,71,80,81]. This evidence concerns the gene CRHR1 and urticaria.