CRHR1 and inflammatory bowel disease: Although the preliminary pilot data from our in vivo mouse experiment require confirmation and translation to the human system, they encourage the full exploration of nasally applied CRH-R1 antagonists in the future therapy of stress-induced MC-dependent nasal mucosa inflammation, in line with previous reports on the therapeutic benefits of CRH-R1 antagonists in inflammatory bowel disease or bladder hyperactivity [52,82].