Taken together, persistent milk signaling apparently stimulates overexpression of tau proteins as well as mTORC1-mediated tau phosphorylation promoting the formation of neurofibrillary tangles, enhances galactose-mediated oxidative stress as well as miR-148a-mediated mitochondrial dysfunction and impaired autophagy, all pathological hallmarks of AD. Here, MAPT is linked to Alzheimer disease.