VEGFA and periodontitis: Patients experienced a reduction of bradykinin (a vasoactive peptide involved in the classical signs of inflammation), local heat, redness, pain, and swelling [95] as well as VEGF, while EGF (a growth factor implicated in wound healing [96]), increased; they concluded that patients with periodontitis had a beneficial effect due to PBM, in the early phases of the revascularisation and healing.