As compared with the adjacent area, the expression of other auto-lysosomal components including lysosomal lipase (LIPA), lysosomal membrane component (LAPTM4A), as well as cathepsin S (CTSS) and cathepsin Z (CTSZ) (two lysosomal cysteine proteinases), was significantly decreased in the carcinoma area (Figure S1). The gene discussed is CTSZ; the disease is carcinoma.