THBS1 and infection: The findings of this study include (1) φAB6-derived TSP can not only inhibit the formation of biofilms and degrade pre-exiting biofilms in vitro, but also destroy the integrity of bacterial membranes; (2) cloaca injection of 20 μg TSP depolymerase is sufficient to protect zebrafish from fatal infection; and (3) treatment of Foley catheter sections with TSP can inhibit colonization by A. baumannii.