CASP9 and breast cancer: TA has been described as an anticancer agent in all the previously mentioned molecular subtypes, found to induce apoptosis in hormone receptors-positive BC cells (MCF-7) [33], HER-2 positive BC cells (BT474) [34] and the triple-negative BC cells (MDA-MB-231) [22] mainly by activating a series of caspases such as caspase 3/7 and caspase 9, as shown in Figure 2 and inhibiting the overly expressed fatty acid synthase in BC cells [22].