PARG and ovarian carcinoma: Mechanistically, it was found that TA enhances the activity of Cisplatin in ovarian carcinoma cells through the inhibition of poly(ADP-ribose) glycohydrolase (PARG) expression, increasing the accumulation of poly(ADP-ribose) (pADPr), following the release of apoptosis-inducing factors, and the activation of caspase-3, as shown in Figure 1 and Figure 2, thus drawing a clear mechanism for how/why TA is recommended in a combinatorial approach with Cisplatin in the treatment of advanced ovarian carcinoma, especially in the case of Cisplatin-resistant patients [27].