Gene encoding anoctamin-1 (ANO1, aliases TMEM16A/DOG1), a calcium-dependent chloride channel protein, locates in 11q13 [8], which is commonly amplified in several cancers, including the breast [9,10], the stomach [11,12], the ovary [13], and the prostate [14,15], glioblastoma [16], and head and neck cancer [10,17,18,19,20]. The gene discussed is ANO1; the disease is head and neck cancer.