Our data revealed that the proliferation of homeostatic microglia in the AD + Toxo group correlated with a significant increase in IL-1β and TNF-α levels and in the expression of trophic factors (Il1β, Tnfα, Mcsf, and NFKB1) (p < 0.05, Figure 2H,I). This evidence concerns the gene CSF1 and Alzheimer disease.