To investigate whether there were any signs of dampened CD8+ T cell activity mediated by PD-L1/PD1 signaling in tumors with high density of CD11c+ APCs, a contrast group analysis specifically addressed whether the ITGAXhighCD8Ahigh gene signature in the TCGA sarcoma cohort was detected also in a CD274 (encoding PD-L1)-rich TME. The gene discussed is CD274; the disease is sarcoma.