PFKFB4 and metastatic malignant neoplasm in the lymph nodes: As shown in Figure 5A,B, the cervical cancer patients with a high CAIX level and high PFKFB4 level (CAIXhigh/PFKFB4high) were more predisposed to advanced clinical stage and lymph node metastasis than those expressing CAIXlow/PFKFB4low, CAIXhigh/PFKFB4low, and CAIXlow/PFKFB4high.