PG can be altered by several processes, such as impaired fibrin formation, altered levels of fibrinolytic factors (for instance PAI-1, α2-antiplasmin, fibrinogen, TAFI, tPA, or uPA), or the interaction of plasmin(ogen) with cellular receptors [20,21,22,23] or pathogens during infections [24]. The gene discussed is PLG; the disease is infection.