Module 4 is mainly associated with the PI3K-Akt signaling pathway (all five genes are upregulated), pathways in cancer (all six genes are upregulated), pancreatic cancer (all three genes are upregulated), proteoglycans in cancer (four genes: three up- and one down-), melanoma (all three genes are upregulated), Rap1 signaling pathway (all four genes are upregulated), Ras signaling pathway (all four genes are upregulated), MAPK signaling pathway (all four genes are upregulated), and bladder cancer (both genes are upregulated) (Table 3). The gene discussed is AKT1; the disease is urinary bladder cancer.