HIF1A and cancer: The KEGG pathway analysis of the hub genes revealed that, in the fourth generation, the hub genes were highly enriched in pathways in cancers (all five genes are upregulated), the cell cycle (all three genes are downregulated), VEGF signaling pathway (all three genes are upregulated), epithelial cell signaling in helicobacter pylori infection (all three genes are upregulated), microRNAs in cancer (five genes: three up- and two down-), FoxO signaling pathway (four genes: two up- and two down-), and in the HIF1 signaling pathway (all three genes are upregulated) (Table 5).