TNF and cancer: However, in the first generation, the enriched pathways were skewed towards the PI3K-Akt signaling pathway, HIF1 signaling pathway, Toll-like receptor signaling, TNF signaling pathway, NOD-like receptor signaling pathway, pathways in cancer, transcriptional misregulation in cancer and microRNAs in cancer, but most of the hub genes associated with these pathways were downregulated (Supplementary Table S8).