Respectively, ATRT-TYR tumours are defined by overexpression of several melanosomal markers, such as MITF, TYR or DCT; the SHH subgroup is characterized by the overexpression of MYCN, GLI2 (SHH signalling targets) and by NOTCH signalling upregulation; ATRT-MYC is named after the marked increase in MYC expression [86]. The gene discussed is MYC; the disease is neoplasm.