All these effects are prevented by the expression of O6-methylguanine-DNA methyltransferase (MGMT) by tumour cells: indeed, the trigger for both the autophagic and the apoptotic responses via ataxia-telangiectasia mutated protein kinase (ATM) activation is represented by the O6MeG TMZ-induced DNA lesion. The gene discussed is MGMT; the disease is neoplasm.