On the contrary, a huge study from Čančer and collaborators reveals that mTOR activation promotes tumour malignancy and aggressiveness in different humanized stem cell models of paediatric SHH MB, either derived from iPSC-reprogrammed neural embryonic stem cells (NES) or from embryonic hindbrain neural stem cells via MYCN lentiviral overexpression [69]. Here, MTOR is linked to neoplasm.