MMP9 and hypertensive disorder: They concluded that localized angiogenic imbalance and decreased MMP-2 and MMP-9 could cause further decline in placental and myoendometrial vascularization and placental and fetal growth in distal as compared with proximal uterus of HTN-Preg rats, in addition to a general reduction in placental and fetal growth during uteroplacental ischemia.