Their study showed that if soluble sFlt-1/PlGF imbalance was corrected by infusing PlGF, decreases in vascular and uteroplacental MMP-2 and MMP-9 could be reversed, as well as increases in MMP-1, MMP-7, and collagen types I and IV induced by placental ischemia and antiangiogenic sFlt-1 could be reversed in hypertensive disorders in pregnancy. Here, PGF is linked to hypertensive disorder.