Interestingly, we reported how the change in plasma S100A4 levels accompanies longitudinal trajectories of insulin resistance in children and how the methylation levels for two-enhancer-related CpG sites of the S100A4 region (cg07245635 and cg10447638) perfectly correlate with insulin resistance biomarkers at the prepubertal stage [121]. This evidence concerns the gene S100A4 and Insulin resistance.