Although no head to head trials with anti-CGRP mAbs and migraine standard prophylactic treatments have been conducted so far, according to a systematic review and a likelihood to help or harm (LHH) analysis [45] anti-CGRP mAbs had higher LHH values than propranolol or topiramate for episodic migraine and onabotulinumtoxinA or topiramate for chronic migraine prevention. Here, CALCA is linked to migraine disorder.