Other genes frequently mutated in ccRCC are located on chromosome 3p as well and include: PBRM1, a subunit of a SWI/SNF chromatin remodeling complex, mutated in 30–40% [1,2,3,6,7,8,9]; BAP1, an ubiquitin hydrolase, mutated in 10–15% [1,2,3,10,11]; and SETD2 H3K36 methyltransferase, mutated in 10% of ccRCCs [1,2,3,12,13]. Here, SETD2 is linked to nonpapillary renal cell carcinoma.