AKT1 and cancer: Since PTEN plays an important role in suppressing the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which is associated with chemotherapeutic drug resistance in cancer cells [79,80,81], its inhibition leads to a PI3K/AKT activation with a consequent increase in cell survival and apoptosis inhibition through phosphorylating of the downstream targets [82,83,84] (Figure 4A,B).