PRKCD and cervical cancer: Meanwhile, in SiHa cells and in a mouse model of cervical cancer, miR-181a was described to play a critical role in modulating resistance to radiation therapy through the negative regulation of Protein Kinase C Delta (PRKCD), a pro-apoptosis gene product, further determining a decrease of the radiation-induced apoptosis and in cell fraction in the G2/M phase that is usually the most sensitive cell sub-population toward the radiation [87].