Additional tumorigenic properties of BC EVs were further elucidated by Yang et al., who demonstrated upregulation of Bcl2 and Cyclin D, downregulation of the pro-apoptotic Bax and Caspase-3, as also a dose dependent inhibition of apoptosis in BC cell lines T24 and 5637, following treatment with BC derived EVs (exosomes) [32]. Here, CASP3 is linked to breast cancer.