Tumor necrosis factor-resistance in a breast cancer cell line was overcome by a TNF immunocytokine targeting human epidermal growth factor 2 (HER-2) via the upregulation of TNF receptor 1 (TNFR1) expression, the activation of caspase-associated apoptosis, and the deactivation the Akt proliferation pathway [86,87]. Here, TNF is linked to breast cancer.