A similar immunocytokine-targeting human leukocyte antigen DR (HLA-DR) demonstrated an enhanced ability to stimulate the apoptosis-promoting signal transducer and activator of transcription 1 (STAT1) pathway in multiple myeloma and lymphoma cells compared to the CD20-specific immunocytokine, but it also mediated toxicity against healthy peripheral blood mononuclear cells (PBMCs) [64]. This evidence concerns the gene STAT1 and plasma cell myeloma.