Another in vitro study regarding the MAPK and Janus kinase (JAK)/STAT pathways showed increased activation of NF-κB and STAT3 in response to TLR7, TLR9 stimulation particularly in peripheral B cells in SS patients with anti-Ro/SS-A antibody and those without extra-glandular lesions [67]. Here, STAT3 is linked to synovial sarcoma.