AKT2 and cervical carcinoma: In addition, a study [67] demonstrated that the interaction of the E6 oncoprotein could also cause a decrease in the expression of a tsmiR, by which HPV16 E6 is able to decrease the level of miR-2861 expression, resulting in the suppression of the EGFR/AKT2/CCND1 pathway in cervical cancer cells.