Hepatic lipotoxicity and non-liver factors, such as inflammation in adipose tissues, are linked to the elevation of proinflammatory cytokines and chemokines as key markers of NASH, such as tumor necrosis factor α (TNF-α), IL-6, chemokine CC ligand-2, and C-reactive protein [72,73,74]. This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.