Bcr–Abl expression, as well as increasing the transactivation function of the RelA/p65 subunit of NF-κB, also leads to the activation of NF-κB-dependent transcription causing nuclear translocation of NF-κB in ALL and CML [183,184,185]. Here, NFKB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.