Resveratrol also induced autophagy in imatinib-sensitive (IM-S) and resistant (IM-R) chronic myelogenous leukaemia (K562) cells via JNK-mediated p62/SQSTM1 expression and AMPK activation [133] (Figure 7). The gene discussed is SQSTM1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.