BCL2 and B-cell chronic lymphocytic leukemia: Furthermore, resveratrol has been shown to increase the production of pro-apoptotic proteins Bax, Bad and Bim in MOLT-4, Jurkat, CEM-C-15 and CEM-C7-14 cells [77], and downregulate Bcl-2 expression in L1210 [99], KG-1a and HL-60 [119,135], Jurkat, Kasumi-1 and SUP-B15 [87], WSU-CLL, B-CLL and ESKOL cells [66].