Rarely, mitochondrial disorders may present with multiple lipomatosis, a rare disorder characterized by the development of non-encapsulated lipomas (especially in patients with mtDNA mutation in the tRNA-lysine gene) [64], or with tumors of adrenals or sympathetic and parasympathetic paraganglia (i.e., paragangliomas and pheochromocytomas, related to nuclear mutations in the subunits of succinate dehydrogenase gene: SDHB, SDHC, SDHD) [65]. Here, SDHC is linked to lipoma.