Mutative TF BRCA1 with abnormal overexpression in breast cancer could not only inhibit miRNA MIR20A to actuate target gene TP53INP2 to trigger autophagy and apoptosis, but also galvanize miRNA MIR19A to drive target genes CXCR4 and ZEB1, which were modified by DNA methylation and phosphorylation, respectively, to promote cell proliferation, angiogenesis, and metastasis. The gene discussed is CXCR4; the disease is breast cancer.