In the first common core signaling pathway in both TNBC and non-TNBC, as shown in Figure 5 with black lines, microenvironment factor CD274, known as programmed death-ligand 1 (PD-L1), can not only simulate cancer cells proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), and metastasis, but also inhibit autophagy, apoptosis, and the immune response through receptor ILDR2. The gene discussed is ILDR2; the disease is cancer.